Estimation of total and ionized magnesium and its correlation with the glycated hemoglobin in newly diagnosed subjects of type 2 Diabetes Mellitus

Abstract

Mg deficiency underlies the mechanism of insulin resistance of conditions associated with altered glucose tolerance, such as t2DM. Despite of many reports showing deranged magnesium level in t2DM, most of these studies have focused on level of t Mg in spite of the fact that iMg is the physiological form. Furthermore, data on iMg in newly diagnosed t2DM yet to start treatment is scarce. Therefore, this study was undertaken to evaluate both tMg and iMg level in newly diagnosed type 2 diabetes mellitus. This study was conducted to evaluate serum levels of tMg and iMg in 30 patients with newly diagnosed t2DM and 30 non-diabetic healthy controls, recruited from the out-patient department of Medicine, BPS Government Medical College for Women, KhanpurKalan, Sonepat, and Haryana. Fasting venous blood was drawn from each participant for the biochemical analysis of FBS, HbA1C, tMg and iMg. The results are Compared to controls, the FBS, HbA1C and tMg levels were significantly increased (1.17±0.50 vs. 0.86±0.10 ; p=0.002), whereas the iMg level was significantly decreased (0.52±0.04 vs. 0.55±0.06; p=0.02) in type 2 diabetic patients. The findings of significant association in non-diabetic control group(r=0.558, p=0.001) and no significant association between tMg and iMg in the patient group (r=0.245, p=0.192) strengthens the concept of altered Mg metabolism in diabetes. There were no significant associations of FBS and HbA1C with tMg and iMg in the diabetic patient group. In conclusion the observation of decreased physiologically active form of Mg (iMg), despite increased total Mg and loss of correlation between tMg and iMg, suggests that Mg metabolism in diabetes is significantly altered though without any relation to glycemic control.

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Cite this paper

@inproceedings{Kulshrestha2015EstimationOT, title={Estimation of total and ionized magnesium and its correlation with the glycated hemoglobin in newly diagnosed subjects of type 2 Diabetes Mellitus}, author={Manish Raj Kulshrestha}, year={2015} }