Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-infected adults.

@article{Schipani2012EstimationOT,
  title={Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-infected adults.},
  author={Alessandro Schipani and Deirdre Egan and Laura J. Dickinson and Geraint Davies and Marta Boffito and Michael Youle and Saye Khoo and David J. Back and Andrew Owen},
  journal={Antiviral therapy},
  year={2012},
  volume={17 5},
  pages={861-8}
}
BACKGROUND The organic anion transporting polypeptides (OATP)/SLCO family represents an important class of hepatic drug uptake transporters that mediate the sodium independent transport of a diverse range of amphipathic organic compounds, including the protease inhibitors. The SLCO1B1 521T>C (rs4149056) single nucleotide polymorphism (SNP) has been consistently associated with reduced transport activity in vivo, and we previously showed an association of this polymorphism with lopinavir plasma… CONTINUE READING
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