Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS

@article{Park2009EstimationOT,
  title={Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS},
  author={Benjamin J Park and Kathleen Wannemuehler and Barbara J. Marston and Nelesh P. Govender and Peter G. Pappas and Tom Chiller},
  journal={AIDS},
  year={2009},
  volume={23},
  pages={525–530}
}
OBJECTIVE Cryptococcal meningitis is one of the most important HIV-related opportunistic infections, especially in the developing world. [...] Key MethodMETHODS We used the median incidence rate of available studies in a geographic region to estimate the region-specific cryptococcal meningitis incidence; this was multiplied by the 2007 United Nations Programme on HIV/AIDS HIV population estimate for each region to estimate cryptococcal meningitis cases.Expand
View on Wolters Kluwer
ncbi.nlm.nih.gov
1,775 Citations
Highly Influential Citations
68
Background Citations
442
Methods Citations
12
Results Citations
2

Paper Mentions

News Article
Найдены регуляторные гены, останавливающие спорообразование у дрожжей Cryptococcus neoformans • Новости науки на «Элементах» • Микробиология, Генетика
elementy.ru
5 February 2019
Interventional Clinical Trial
Treatment With Tamoxifen in Cryptococcal Meningitis
The purpose of this study is to develop initial efficacy, feasibility, and safety data regarding the use of Tamoxifen in combination with amphotericin B and fluconazole in the… Expand
ConditionsHiv, Meningitis, Meningitis Streptococcal, (+1 more)
InterventionDrug
Oxford University Clinical Research Unit, Vietnam
October 2017 - July 2018

1,775 Citations

Citation Type

Citation Type

Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis.
TLDR
The analysis highlights the substantial ongoing burden of HIV-associated cryptococcal disease, primarily in sub-Saharan Africa, which is a metric of HIV treatment programme failure; timely HIV testing and rapid linkage to care remain an urgent priority. Expand
Original Research: A medical audit of the management of cryptococcal meningitis in HIV-positive patients
  • 2012
Cryptococcal meningitis (CM) is caused by an opportunistic encapsulated yeast, Cryptococcus neoformans. Despite recent expansion of antiretroviral treatment (ART) programmes in developing countries,… Expand
Prevalence, correlates, and outcomes of cryptococcal antigen positivity among patients with AIDS, United States, 1986-2012.
TLDR
The prevalence of cryptococcal infection among advanced AIDS patients in the United States was high and above the published cost-effectiveness threshold for routine screening, and routine CrAg screening among human immunodeficiency virus-infected patients with a CD4 count ≤100 cells/µL is recommended to detect and treat early infection. Expand
High ongoing burden of cryptococcal disease in Africa despite antiretroviral roll out.
TLDR
The results show that the “treatment gap” is not narrowed, and AIDS-related illness such as cryptococcal meningitis and the associated mortality are not reduced, despite a major effort to expand access to ART throughout sub-Saharan Africa over recent years. Expand
Prevalence and Correlates of Cryptococcal Antigen Positivity Among AIDS Patients — United States, 1986–2012
TLDR
To quantify the prevalence of undiagnosed cryptococcal infection in HIV-infected persons in the United States during 1986-2012, stored sera from 1,872 participants in the Multicenter AIDS Cohort Study and the Women's Interagency HIV Study with CD4 T-cell counts <100 cells/µL were screened for CrAg, which indicated the overall prevalence of CrAg positivity to be 2.9%. Expand
Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy
TLDR
Protective immune responses in HIV-associated cases, immunogenetic predisposition to infection, and the role of immune-mediated pathology in patients with non-HIV associated infection and in the context of HIV- associated immune reconstitution reactions are better understood. Expand
Public Health Importance of Cryptococcal Disease: Epidemiology, Burden, and Control
This chapter focuses primarily on HIV-associated cryptococcosis, due to its much greater public health burden, and discusses the challenges to public health agencies in addressing the threat of… Expand
HIV-Associated Cryptococcal Disease in Resource-Limited Settings: A Case for “Prevention Is Better Than Cure”?
TLDR
Early diagnosis, proactive antifungal therapy with concurrent management of raised intracranial pressure creates the potential to markedly reduce mortality associated with this disease. Expand
Treatment of Cryptococcal Meningitis in KwaZulu-Natal, South Africa
TLDR
Even in a setting where amphotericin B is available, mortality from cryptococcal meningitis in this setting is high, particularly in the immediate period after diagnosis, which highlights the still unmet need not only for earlier diagnosis of HIV and timely access to treatment of opportunistic infections, but for better treatment strategies. Expand
High Prevalence of Cryptococcal Antigenemia among HIV-infected Patients Receiving Antiretroviral Therapy in Ethiopia
TLDR
Cryptococcal antigenemia is high in Ethiopia and rapid scale up of screening programs is needed, and Screening should be implemented for HIV-infected patients with low CD4 counts regardless of symptoms or receipt of ART. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 55 REFERENCES
Cryptococcal infection in a cohort of HIV-1-infected Ugandan adults
Objective Despite the recognition of Cryptococcus neoformans as a major cause of meningitis in HIV-infected adults in sub-Saharan Africa, little is known about the relative importance of this… Expand
Population-based surveillance for cryptococcosis in an antiretroviral-naive South African province with a high HIV seroprevalence
TLDR
This study demonstrates the high disease burden due to cryptococcosis in an antiretroviral-naive South African population and emphasizes the need to improve early recognition, diagnosis and treatment of the condition. Expand
Cryptococcal meningitis in human immunodeficiency virus-infected patients in Harare, Zimbabwe.
TLDR
This study provides a unique basis for the development of novel management strategies for patients with cryptococcal meningitis who reside in resource-poor countries. Expand
Bacterial meningitis in Malawian adults: pneumococcal disease is common, severe, and seasonal.
  • S. Gordon, A. Walsh, +5 authors R. Read
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2000
TLDR
Despite the HIV-related pattern of infecting pathogens among these cases of meningitis and the increased incidence of the condition, there was evidence that the typical seasonal pattern of pneumococcalMeningitis, which peaks in the cold, dry season, was preserved. Expand
Cryptococcosis: population-based multistate active surveillance and risk factors in human immunodeficiency virus-infected persons. Cryptococcal Active Surveillance Group.
TLDR
To determine the incidence of cryptococcosis and its risk factors among human immunodeficiency virus (HIV)-infected persons, population-based active surveillance was conducted in four US areas during 1992-1994 and a case-control study was done. Expand
The changing epidemiology of cryptococcosis: an update from population-based active surveillance in 2 large metropolitan areas, 1992-2000.
  • S. Mirza, M. Phelan, +8 authors R. Hajjeh
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2003
TLDR
It is suggested that HIV-infected persons who continue to develop cryptococcosis in the era of highly active antiretroviral therapy (HAART) in the United States are those with limited access to health care and more efforts are needed to expand the availability of HAART and routine HIV care services. Expand
The Impact of HIV on Meningitis as Seen at a South African Academic Hospital (1994 to 1998)
TLDR
Over a 4-year period the HIV epidemic was responsible for a marked shift in the spectrum of meningitis towards chronic infections such as TB and cryptococcalMeningitis at the PAH. Expand
AIDS-associated cryptococcal meningitis in Rwanda (1983-1992): epidemiologic and diagnostic features.
TLDR
CM is an important opportunistic infection among AIDS patients in Central Africa and remains a problematic diagnosis in areas with limited diagnostic facilities. Expand
Clinical and epidemiologic trends in HIV/AIDS patients in a hospital setting of Yaoundé, Cameroon: a 6-year perspective.
TLDR
The increasing clinical and epidemiologic trends of the HIV/AIDS pandemic within the hospital show the devastation and socio-economic impact, especially on the Cameroonian youth and women. Expand
Epidemiology and clinical features of HIV infection/AIDS in Korea.
TLDR
The epidemiological and clinical patterns of HIV infection/AIDS in Korea is investigated by retrospectively analyzing the medical records of 176 HIV-infected persons who visited two major referral hospitals of AIDS in Korea from 1985 to April 2000 to aid in establishing effective preventive measures and treatment guidelines. Expand
...
1
2
3
4
5
...