Estimation of the composition of heparin mixtures from various origins using proton nuclear magnetic resonance and multivariate calibration methods.

@article{RuizCalero2002EstimationOT,
  title={Estimation of the composition of heparin mixtures from various origins using proton nuclear magnetic resonance and multivariate calibration methods.},
  author={Victoria Ruiz-Calero and Javier Saurina and Teresa M Galceran and Santiago Hern{\'a}ndez-Cassou and Llu{\'i}s Puignou},
  journal={Analytical and bioanalytical chemistry},
  year={2002},
  volume={373 4-5},
  pages={259-265}
}
A multivariate calibration method for the characterization of heparin samples based on the analysis of 1H nuclear magnetic resonance (NMR) spectral data is proposed. Heparin samples under study consisted of two-component or four-component mixtures of heparins from porcine, ovine and bovine mucosae and bovine lung. Although the 1H NMR spectra of all heparin types were highly overlapping, each origin showed some particular features that could be advantageously used for the quantification of the… CONTINUE READING

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