Estimation of the Incidence and Factors Predictive of Corneal Scarring in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study

@article{Barr2006EstimationOT,
  title={Estimation of the Incidence and Factors Predictive of Corneal Scarring in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study},
  author={Joseph T. Barr and Bradley S. Wilson and Mae Gordon and Marjorie J. Rah and Colleen Riley and Pete S Kollbaum and Karla Zadnik},
  journal={Cornea},
  year={2006},
  volume={25},
  pages={16-25}
}
Purpose: The multicenter Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study is a prospective, observational study of 1209 keratoconus patients. We report methods to define incident corneal scarring and baseline factors predictive of incident corneal scarring in nonsurgical eyes of CLEK Study keratoconus patients through their fifth year of follow-up. Methods: Of the 1209 patients, 878 patients with at least one unscarred cornea at baseline were included in this study. The… Expand
The Correlation between Corneal Findings and Disease Severity in Keratoconus per Scheimpflug Corneal Tomography
TLDR
The presence of apical scarring and Fleischer rings on biomicroscopy can aid the clinician in making the distinction between severe or long-standing disease (respectively) and is associated with worse BSCVA and tomography findings. Expand
Risk factors and association with severity of keratoconus: the Australian study of Keratoconus
Our results show that asthmatic patients tend to have more severe KC and thus close monitoring for disease progression would be advised, and appropriate treatment strategies may be actioned stabiliseExpand
Objective and Subjective Evaluation of Clinical Performance of Scleral Lens with Varying Limbal Clearance in Keratoconus
TLDR
Although low LC might result in more compression-related changes to ocular surface, high LC is associated with greater comfort and greater edematous changes, and may play an important role in subjective performance in scleral lenses. Expand
Performance and predictability of a new large diameter contact lens design in keratoconic corneae.
TLDR
Corneoscleral RGP contact lenses are a safe, and effective alternative for managing KCN patients to corneal lenses, and could be used to help to decide the first diagnostic lens to be assessed, easing the overall fitting process. Expand
Comparative Analysis of Tear Proteins in Keratoconic Scleral Lens Wearers with Variation in Limbal Clearance.
TLDR
Relative changes in the cytokine and protease levels were found when comparing low and high limbal clearance, indicating that the midperipheral lens fit is an important feature that can impact the inflammatory response of the keratoconic eye. Expand
Intrastromal corneal ring segments for treating keratoconus.
TLDR
To evaluate the effectiveness and safety of intrastromal corneal ring segments as a treatment for keratoconus, the Cochrane Central Register of Controlled Trials (CENTRAL) was searched and no RCTs were found. Expand
Comparison of Corneal Higher-order Aberrations between Miniscleral and Hybrid Lenses in Keratoconus
TLDR
The results of this study showed the effectiveness of both miniscleral and hybrid lenses in decreasing HOAs in keratoconus patients. Expand
Effects of a semi-scleral contact lens on refraction and higher order aberrations.
TLDR
Rose K2 XL semi-scleral contact lenses were effective in improving vision and reducing ocular aberrations for eyes with irregular corneas and Magnitudes of group changes reflected the magnitudes before lens wear. Expand
UVA-light and Riboflavin-mediated Corneal Collagen Cross-linking
Keratoconus and other corneal conditions associated with progressive stromal thinning including keratectasia after laser-assisted in situ keratomileusis (LASIK) and pellucid marginal degenerationExpand
Customised aberration‐controlling corrections for keratoconic patients using contact lenses
  • A. Jinabhai
  • Medicine
  • Clinical & experimental optometry
  • 2019
TLDR
Improvements in visual performance and comfortable wearing times, as provided by customised lenses, could help to reduce the rate of keratoplasty in keratoconic patients, thereby significantly reducing clinical issues related to corneal graft surgery. Expand
...
1
2
...