Estimation of population characteristics of pharmacokinetic parameters from routine clinical data

@article{Sheiner1977EstimationOP,
  title={Estimation of population characteristics of pharmacokinetic parameters from routine clinical data},
  author={Lewis B. Sheiner and Barr Rosenberg and Vinay V. Marathe},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1977},
  volume={5},
  pages={445-479}
}
A general data analysis technique estimates average population values of pharmacokinetic parameters and their interindividual variability from clinical pharmacokinetic data gathered during the routine care of patients. Several drug concentration values from each individual, along with dosage information and the values of other routinely assessed variables suffice for purposes of analysis. The Maximum Likelihood principle estimates underlying population values without the necessity for the… CONTINUE READING

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