Estimation of pharmacokinetic parameters of sodium tungstate after multiple-dose during preclinical studies in beagle dogs.

Abstract

In this paper, an empirical Bayes methodology was used to determine the pharmacokinetic profile of sodium tungstate in beagle dogs after multiple oral dosing using the P-PHARM computer program. The population estimation algorithm used in P-PHARM is an EM-type procedure. Sodium tungstate was administered orally, three times a day, (i) for 11 days (21 and 42… (More)

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Cite this paper

@article{Lamer2001EstimationOP, title={Estimation of pharmacokinetic parameters of sodium tungstate after multiple-dose during preclinical studies in beagle dogs.}, author={Sophie Le Lamer and Guilhem Cros and J. J. Serrano and Carme Pi{\~n}ol and J Fern{\"a}ndez-Alvarez and Françoise Bressolle}, journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences}, year={2001}, volume={14 4}, pages={323-9} }