Estimation of parameters in large offspring number models and ratios of coalescence times.

@article{Eldon2011EstimationOP,
  title={Estimation of parameters in large offspring number models and ratios of coalescence times.},
  author={Bjarki Eldon},
  journal={Theoretical population biology},
  year={2011},
  volume={80 1},
  pages={16-28}
}
The ratio of singletons to the total number of segregating sites is used to estimate a reproduction parameter in a population model of large offspring numbers without having to jointly estimate the mutation rate. For neutral genetic variation, the ratio of singletons to the total number of segregating sites is equivalent to the ratio of total length of external branches to the total length of the gene genealogy. A multinomial maximum likelihood method that takes into account more frequency… CONTINUE READING

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