Estimation of paclitaxel biodistribution and uptake in human-derived xenografts in vivo with (18)F-fluoropaclitaxel.

@article{Gangloff2005EstimationOP,
  title={Estimation of paclitaxel biodistribution and uptake in human-derived xenografts in vivo with (18)F-fluoropaclitaxel.},
  author={Anne Gangloff and Wei-Ann Hsueh and Amanda L Kesner and Dale O. Kiesewetter and Betty S. Pio and Mark D. Pegram and Malgorzata Beryt and Allison Townsend and Johannes G Czernin and Michael E. Phelps and Daniel H. S. Silverman},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2005},
  volume={46 11},
  pages={1866-71}
}
UNLABELLED Paclitaxel (PAC) is widely used as a chemotherapy drug in the treatment of various malignancies, including breast, ovarian, and lung cancers. We examined the biodistribution of (18)F-fluoropaclitaxel ((18)F-FPAC) in mice with and without human breast cancer tumor xenografts by use of small-animal-dedicated PET (microPET) and clinically practical semiquantitative methods. We compared the PET data to data derived from direct harvesting and analysis of blood, organs, and breast… CONTINUE READING

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