Estimation of maximum transdermal flux of nonionized xenobiotics from basic physicochemical determinants.

@article{Milewski2012EstimationOM,
  title={Estimation of maximum transdermal flux of nonionized xenobiotics from basic physicochemical determinants.},
  author={Mikolaj Milewski and Audra L Stinchcomb},
  journal={Molecular pharmaceutics},
  year={2012},
  volume={9 7},
  pages={2111-20}
}
An ability to estimate the maximum flux of a xenobiotic across skin is desirable from the perspective of both drug delivery and toxicology. While there is an abundance of mathematical models describing the estimation of drug permeability coefficients, there are relatively few that focus on the maximum flux. This article reports and evaluates a simple and easy-to-use predictive model for the estimation of maximum transdermal flux of xenobiotics based on three common molecular descriptors… CONTINUE READING