Estimation of linkage disequilibrium in randomly mating populations

  title={Estimation of linkage disequilibrium in randomly mating populations},
  author={W G Hill},
SummaryThe degree of linkage disequilibrium, D, between two loci can be estimated by maximum likelihood from the frequency of diploid genotypes in a sample from a random-mating population. Haploid genotypes can be identified directly in some species from a sample of chromosomes extracted from the population and made homozygous, or by test crossing. The maximum likelihood estimators of D are described, with examples, for both methods, including the cases where both loci are codominant and one or… CONTINUE READING
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