Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma.

@article{Cucchetti2014EstimationOL,
  title={Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma.},
  author={Alessandro Cucchetti and Franco Trevisani and Anna Pecorelli and Virginia Erroi and Fabio Farinati and Francesca Ciccarese and Gian Ludovico Rapaccini and Mariella Di Marco and Eugenio Caturelli and Edoardo Giovanni Giannini and Marco Zoli and Franco Borzio and Giuseppe Cabibbo and Martina Felder and Antonio Gasbarrini and Rodolfo Sacco and Francesco Giuseppe Foschi and Gabriele Missale and Filomena Morisco and Gianluca Svegliati Baroni and Roberto Virdone and Mauro Bernardi and Antonio Daniele Pinna},
  journal={Journal of hepatology},
  year={2014},
  volume={61 2},
  pages={
          333-41
        }
}
BACKGROUND & AIMS Lead-time is the time by which diagnosis is anticipated by screening/surveillance with respect to the symptomatic detection of a disease. Any screening program, including surveillance for hepatocellular carcinoma (HCC), is subject to lead-time bias. Data regarding lead-time for HCC are lacking. Aims of the present study were to calculate lead-time and to assess its impact on the benefit obtainable from the surveillance of cirrhotic patients. METHODS One-thousand three… CONTINUE READING

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