Estimation of inbreeding coefficients from genotypic data on multiple alleles, and application to estimation of clonality in malaria parasites.

@article{Hill1995EstimationOI,
  title={Estimation of inbreeding coefficients from genotypic data on multiple alleles, and application to estimation of clonality in malaria parasites.},
  author={W G Hill and Hamza A. Babiker and Lisa C Ranford-Cartwright and David Walliker},
  journal={Genetical research},
  year={1995},
  volume={65 1},
  pages={53-61}
}
Methods for estimating probability of identity by descent (f) are derived for data on numbers of genotypes at single loci and at pairs of loci with many alleles at each locus. The methods are general, but are specifically applied to data on genotype frequencies in zygotes of the malaria parasite sampled from its mosquito host in order to find the extent of outcrossing in the parasite and the degree of clonality in populations. It is assumed that zygotes are the outcome either of gametes of the… CONTINUE READING

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