Estimation of glomerular volume: a comparison of four methods.

  title={Estimation of glomerular volume: a comparison of four methods.},
  author={Pascale H. Lane and Michael W. Steffes and S. Michael Mauer},
  journal={Kidney international},
  volume={41 4},
Methods for estimating glomerular volume were compared in Zenker-fixed, paraffin-embedded biopsies from 10 patients with insulin-dependent diabetes mellitus and 6 normal kidney donors. Two methods of measurement of individual glomerular volumes were used: the Cavalieri method (considered the "gold standard") and the maximal profile area (MPA) method. Also studied were the method of Weibel and Gomez and a method based on the disector principle; both estimate mean volume (VG). MPA and Cavalieri… CONTINUE READING