Estimation of fractions metabolized by hepatic CYP enzymes using a concept of inter-system extrapolation factors (ISEFs) - a comparison with the chemical inhibition method.

@article{Umehara2017EstimationOF,
  title={Estimation of fractions metabolized by hepatic CYP enzymes using a concept of inter-system extrapolation factors (ISEFs) - a comparison with the chemical inhibition method.},
  author={Ken-Ichi Umehara and Felix Huth and Helen Gu and Herbert B. Schiller and Tycho H. Heimbach and Handan He},
  journal={Drug metabolism and personalized therapy},
  year={2017},
  volume={32 4},
  pages={
          191-200
        }
}
BACKGROUND For estimation of fractions metabolized (fm) by different hepatic recombinant human CYP enzymes (rhCYP), calculation of inter-system extrapolation factors (ISEFs) has been proposed. METHODS ISEF values for CYP1A2, CYP2C19 and CYP3A4/5 were measured. A CYP2C9 ISEF was taken from a previous report. Using a set of compounds, fractions metabolized by CYP enzymes (fm,CYP) values calculated with the ISEFs based on rhCYP data were compared with those from the chemical inhibition data… CONTINUE READING
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