# Estimation of evolutionary distances between nucleotide sequences

@article{Zharkikh2004EstimationOE, title={Estimation of evolutionary distances between nucleotide sequences}, author={Andrey A. Zharkikh}, journal={Journal of Molecular Evolution}, year={2004}, volume={39}, pages={315-329} }

A formal mathematical analysis of the substitution process in nucleotide sequence evolution was done in terms of the Markov process. By using matrix algebra theory, the theoretical foundation of Barry and Hartigan's (Stat. Sci. 2:191–210, 1987) and Lanave et al.'s (J. Mol. Evol. 20:86–93, 1984) methods was provided. Extensive computer simulation was used to compare the accuracy and effectiveness of various methods for estimating the evolutionary distance between two nucleotide sequences. It was…

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