Estimation of estrogenic and anti-estrogenic activities of some phthalate diesters and monoesters by MCF-7 cell proliferation assay in vitro.

@article{Okubo2003EstimationOE,
  title={Estimation of estrogenic and anti-estrogenic activities of some phthalate diesters and monoesters by MCF-7 cell proliferation assay in vitro.},
  author={Tomoko Okubo and Toshinari Suzuki and Yoshiko Yokoyama and Kazutaka Kano and Itsu Kano},
  journal={Biological & pharmaceutical bulletin},
  year={2003},
  volume={26 8},
  pages={1219-24}
}
Phthalates are man-made chemicals abundantly found in the environment. Estrogenic activities of phthalate di and monoesters were studied by in vitro assay of human breast cancer MCF-7 cell proliferation. Since phthalate monoesters are formed from diesters by degradation and are found in the environment, we selected some phthalate monoesters in addition to diesters. Among 19 compounds tested, dicyclohexyl phthalate (DCHP), di(2-ethylhexyl) phthalate (DEHP) and butyl benzyl phthalate (BBP) were… CONTINUE READING

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