Estimation of dynamical model parameters taking into account undetectable marker values

@article{Thibaut2006EstimationOD,
  title={Estimation of dynamical model parameters taking into account undetectable marker values},
  author={Rodolphe Thi{\'e}baut and J{\'e}r{\'e}mie Guedj and H{\'e}l{\`e}ne Jacqmin-Gadda and Genevi{\`e}ve Ch{\^e}ne and Pascale Trimoulet and Didier Neau and Daniel Commenges},
  journal={BMC Medical Research Methodology},
  year={2006},
  volume={6},
  pages={38 - 38}
}
BACKGROUND Mathematical models are widely used for studying the dynamic of infectious agents such as hepatitis C virus (HCV). Most often, model parameters are estimated using standard least-square procedures for each individual. Hierarchical models have been proposed in such applications. However, another issue is the left-censoring (undetectable values) of plasma viral load due to the lack of sensitivity of assays used for quantification. A method is proposed to take into account left-censored… CONTINUE READING

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