Estimation of dopamine D2 receptor binding potential in the striatum with iodine-123-IBZM SPECT: technical and interobserver variability.

@article{Verhoeff1993EstimationOD,
  title={Estimation of dopamine D2 receptor binding potential in the striatum with iodine-123-IBZM SPECT: technical and interobserver variability.},
  author={Nicolaas Paul L. G. Verhoeff and Ozlem L. Kapucu and E Sokole-Busemann and E A van Royen and Anthony G. Janssen},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1993},
  volume={34 12},
  pages={2076-84}
}
Factors contributing to the quantification of the striatal dopamine D2 receptor binding potential in vivo using 123I-iodobenzamide (123I-IBZM) and SPECT were analyzed in phantom studies, healthy volunteers and in patients with the parkinsonian syndrome. A cylindrical brain phantom based on a stereotactic brain atlas was constructed with independently fillable compartments representing two striata (ST), cerebellum (CB) and background. Clinical 123I-IBZM SPECT studies were performed on 15 healthy… CONTINUE READING