Estimation of data-specific constitutive exons with RNA-Seq data

  title={Estimation of data-specific constitutive exons with RNA-Seq data},
  author={Ellis Patrick and Michael J. Buckley and Jean Yee Hwa Yang},
  booktitle={BMC Bioinformatics},
RNA-Seq has the potential to answer many diverse and interesting questions about the inner workings of cells. Estimating changes in the overall transcription of a gene is not straightforward. Changes in overall gene transcription can easily be confounded with changes in exon usage which alter the lengths of transcripts produced by a gene. Measuring the expression of constitutive exons— exons which are consistently conserved after splicing— offers an unbiased estimation of the overall… CONTINUE READING
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