Estimation of clinical trial success rates and related parameters

  title={Estimation of clinical trial success rates and related parameters},
  author={C. H. Wong and K. W. Siah and A. Lo},
  journal={Biostatistics (Oxford, England)},
  pages={273 - 286}
  • C. H. Wong, K. W. Siah, A. Lo
  • Published 2019
  • Medicine
  • Biostatistics (Oxford, England)
  • &NA; Previous estimates of drug development success rates rely on relatively small samples from databases curated by the pharmaceutical industry and are subject to potential selection biases. Using a sample of 406 038 entries of clinical trial data for over 21 143 compounds from January 1, 2000 to October 31, 2015, we estimate aggregate clinical trial success rates and durations. We also compute disaggregated estimates across several trial features including disease type, clinical phase… CONTINUE READING
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