Estimation of blood cellular heterogeneity in newborns and children for epigenome-wide association studies.

@article{Yousefi2015EstimationOB,
  title={Estimation of blood cellular heterogeneity in newborns and children for epigenome-wide association studies.},
  author={Paul Yousefi and Karen Huen and Hong L. Quach and Girish Motwani and Alan E. Hubbard and Brenda Eskenazi and Nina Titenko Holland},
  journal={Environmental and molecular mutagenesis},
  year={2015},
  volume={56 9},
  pages={751-8}
}
Confounding by cellular heterogeneity has become a major concern for epigenome-wide association studies (EWAS) in peripheral blood samples from population and clinical studies. Adjusting for white blood cell percentage estimates produced by the minfi implementation of the Houseman algorithm (minfi) during statistical analysis is now an established method to account for this bias in adults. However, minfi has not been benchmarked against white blood cell counts in children that may differ… CONTINUE READING
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Hematology of Infancy and Childhood, 2nd ed

  • DG Nathan, FA Oski
  • 1981
Highly Influential
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