Estimation of binding rate constants using a simultaneous mixed-effects method: application to monoamine transporter reuptake inhibitor reboxetine.


BACKGROUND AND PURPOSE Reboxetine is a clinically used antidepressant and is a racemic mixture of two enantiomers, SS- and RR-reboxetine. The aim of the work described in this manuscript was to determine the kinetics of binding of the RR- and SS-reboxetine to the human noradrenaline transporter (hNET). EXPERIMENTAL APPROACH We have applied a simultaneous… (More)
DOI: 10.1111/j.1476-5381.2010.00719.x


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