Estimation of autistic children by metallomics analysis

@article{Yasuda2013EstimationOA,
  title={Estimation of autistic children by metallomics analysis},
  author={Hiroshi Yasuda and Yuichi Yasuda and Toyoharu Tsutsui},
  journal={Scientific Reports},
  year={2013},
  volume={3}
}
Clarification of the pathogenesis and treatment of autism spectrum disorders is one of the challenges today. In this study, we examine scalp hair concentrations of 26 trace elements for 1,967 children with autistic disorders (1,553 males and 414 females). Five-hundred and eighty-four (29.7%), 347 (17.6%) and 114 (5.8%) subjects was found deficient in zinc, magnesium and calcium, respectively, and 2.0% or less in the other essential metals. The incidence rate of mineral deficiency was highly… 
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It can be concluded that Chinese autistic children suffer from multi‐chemical element imbalances which involves a complex combination of genetic and environmental factors.
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TLDR
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TLDR
Results indicate that severity of certain symptoms in autism is associated with thyroid function, and in the group of adolescents over 14 years of age, it was also observed that CARS10 (anxiety reaction) negatively correlates with serum TSH levels, and among younger individuals, CARS9 (near receptor responsiveness, taste, smell) positively correlates with TSH.
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CORRIGENDUM: Estimation of autistic children by metallomics analysis
TLDR
It is suggested that infantile zinc- and magnesium-deficiency and/or toxic metal burdens may epigenetically play principal roles as environmental factors in autistic disorders and that metallomics approach may lead to early screening and prevention of the neurodevelopment disorders.
Infantile zinc deficiency: Association with autism spectrum disorders
TLDR
It is suggested that infantile zinc deficiency may epigenetically contribute to the pathogenesis of autism and nutritional approach may yield a novel hope for its treatment and prevention.
Analyses of toxic metals and essential minerals in the hair of arizona children with autism and associated conditions, and their mothers
TLDR
Low iodine levels are consistent with previous reports of abnormal thyroid function, which likely affected development of speech and cognitive skills, and low lithium levels in the mothers likely caused low levels of lithium in the young children, which could have affected their neurological and immunological development.
Mineral Imbalance in Children with Autistic Disorders
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Findings indicate that autistic children are suffered from a global lnineral deficiency in various trace elements, with individuals being exposed to a marked accumulation of several elements.
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The transition metal zinc is an essential element for normal development and function of biological systems including the central nervous system (CNS). Zinc may be an important trace element for the
Toxic trace elements in the hair of children with autism
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TLDR
In-hair concentration levels of antimony, uranium, arsenic, beryllium, mercury, cadmium, lead and aluminum from 40 boys with autism and 40 healthy boys were determined by Perkin-Elmer mass spectrometry and the children with autism had significantly (p < 0.001) higher in-hair concentrations of lead, mercury and uranium.
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TLDR
The conclusion from the investigations is that magnesium deficiency in children with ADHD occurs more frequently than in healthy children.
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TLDR
The aluminum concentrations in scalp hair of total 1,720 Japanese children are surveyed for estimating their body burden, in comparison with those of adults, and it is demonstrated that the young children aged 0-9 years have suffered from high exposure to this toxic metal.
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TLDR
It is suggested that the behavioral improvement observed with the combination vitamin B6-magnesium in PDD/autism is associated with concomitant modifications of Erc-Mg values.
Level of Trace Elements (Copper, Zinc, Magnesium and Selenium) and Toxic Elements (Lead and Mercury) in the Hair and Nail of Children with Autism
TLDR
The study observed a valid indication of Cu body burden in the autistic children and showed a significant elevation in the concentration of Cu, Pb, and Hg and significant decrease in the concentrate of Mg and Se observed in the hair and nail samples of autistic subjects could be well correlated with their degrees of severity.
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