Estimation of autistic children by metallomics analysis

@article{Yasuda2013EstimationOA,
  title={Estimation of autistic children by metallomics analysis},
  author={Hiroshi Yasuda and Yuichi Yasuda and Toyoharu Tsutsui},
  journal={Scientific Reports},
  year={2013},
  volume={3}
}
Clarification of the pathogenesis and treatment of autism spectrum disorders is one of the challenges today. In this study, we examine scalp hair concentrations of 26 trace elements for 1,967 children with autistic disorders (1,553 males and 414 females). Five-hundred and eighty-four (29.7%), 347 (17.6%) and 114 (5.8%) subjects was found deficient in zinc, magnesium and calcium, respectively, and 2.0% or less in the other essential metals. The incidence rate of mineral deficiency was highly… 
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TLDR
The findings suggest that infantile zinc- and magnesium-deficiency and/or toxic metal burdens may be critical and induce epigenetic alterations in the genes and genetic regulation mechanisms of neurodevelopment in the autistic children, and demonstrate that a time factor “infantile window” is also critical for neurodevelopment and probably for therapy.
Analysis of lead, arsenic and calcium content in the hair of children with autism spectrum disorder
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According to the observations, children diagnosed with ASD suffer from Ca deficiency and toxic metal overload (As and Pb).
Oxidative stress indices in ASD children in Sub-Sahara Africa
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Reduction in Zn and Mg levels with a concurrent increase in Pb in children with ASD in this study may be the basis of inadequate TAC manifesting as increased MDA and reduced TPP levels.
A case–control study on the relationship between urine trace element levels and autism spectrum disorder among Iranian children
Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder characterized mainly by qualitative deficiencies in social communication skills, accompanied by repetitive and restricted…
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The zinc concentration in hair from 28,424 Japanese subjects was measured and found that infants and elderlies are prone to zinc deficiency and that intervention of zinc deficiency is necessary for normal human development, health and longevity.
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A systematic review of trace element measures in autism spectrum disorder found significant differences in the content of trace elements between patients with ASD compared to controls, helping highlighting the role of Trace elements as environmental factors in the etiology of ASD.
Chinese children with autism: A multiple chemical elements profile in erythrocytes
TLDR
It can be concluded that Chinese autistic children suffer from multi‐chemical element imbalances which involves a complex combination of genetic and environmental factors.
Association Between Essential Metal Elements and the Risk of Autism in Chinese Han Population.
TLDR
It is suggested that the higher levels of Ca, K, and Mg and lower levels of Zn and Cu may be associated with an elevated risk of ASD.
Metallomics Analysis for Assessment of Toxic Metal Burdens in Infants/Children and Their Mothers: Early Assessment and Intervention Are Essential
TLDR
The findings suggest that these toxic metal burdens and essential metal deficiencies in infants/children are of serious concern for their neurodevelopment, indicating that the early assessment and intervention are crucial.
Research into the Association of Cadmium and Manganese Excretion with Thyroid Function and Behavioral Areas in Adolescents with Autism Spectrum Disorders
TLDR
Results indicate that severity of certain symptoms in autism is associated with thyroid function, and in the group of adolescents over 14 years of age, it was also observed that CARS10 (anxiety reaction) negatively correlates with serum TSH levels, and among younger individuals, CARS9 (near receptor responsiveness, taste, smell) positively correlates with TSH.
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References

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CORRIGENDUM: Estimation of autistic children by metallomics analysis
TLDR
It is suggested that infantile zinc- and magnesium-deficiency and/or toxic metal burdens may epigenetically play principal roles as environmental factors in autistic disorders and that metallomics approach may lead to early screening and prevention of the neurodevelopment disorders.
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It is suggested that infantile zinc deficiency may epigenetically contribute to the pathogenesis of autism and nutritional approach may yield a novel hope for its treatment and prevention.
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Findings indicate that autistic children are suffered from a global lnineral deficiency in various trace elements, with individuals being exposed to a marked accumulation of several elements.
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TLDR
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TLDR
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TLDR
The study observed a valid indication of Cu body burden in the autistic children and showed a significant elevation in the concentration of Cu, Pb, and Hg and significant decrease in the concentrate of Mg and Se observed in the hair and nail samples of autistic subjects could be well correlated with their degrees of severity.
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