Estimation of TCA cycle flux, aminotransferase flux, and anaplerosis in heart: validation with syntactic model.

@article{Cohen1995EstimationOT,
  title={Estimation of TCA cycle flux, aminotransferase flux, and anaplerosis in heart: validation with syntactic model.},
  author={David M. Cohen and Richard N Bergman},
  journal={The American journal of physiology},
  year={1995},
  volume={268 3 Pt 1},
  pages={E397-409}
}
Weiss et al. (Circ. Res. 70: 392-408, 1992) proposed a model of the citric acid cycle (CAC) in myocytes and a system of 17 differential equations that can be used to describe the changes over time in enrichment of carbons C-2 and C-4 of glutamate under conditions of metabolic steady state. They also proposed an empirical measure (KT) of flux through the CAC… CONTINUE READING