Estimation of Secondary Structure in Ribonucleic Acids

  title={Estimation of Secondary Structure in Ribonucleic Acids},
  author={Ignacio Tinoco and O. C. Uhlenbeck and MARK D. Levine},
A simple method for estimating the secondary structure of an RNA molecule has been proposed on the basis of the knowledge of its sequence. 

Improved estimation of secondary structure in ribonucleic acids.

This method can be used for predicting and assessing possible secondary structures for recently determined RNA sequences and new experimental and theoretical results allow us to improve the method, without making it more complicated.

Implications of secondary structure in messenger RNA.

  • L. A. Ball
  • Biology
    Journal of theoretical biology
  • 1972

RNA structure prediction.

The main approaches to RNA structure prediction are discussed: combinatorial approaches, comparative approaches, and kinetic approaches.

Determinant of cistron specificity in bacterial ribosomes

Complementarity relationships between this sequence and a purine-rich tract in the ribosome binding site of different bacterial mRNAs suggest that the 3′-end of 16S RNA determines the intrinsic capacity of ribosomes to translate a particular cistron.

A parallel algorithm for estimating the secondary structure in ribonucleic acids

A parallel algorithm for estimating the secondary structure of an RNA molecule is presented in this paper. The mathematical problem to compute an optimal folding based on free-energy minimization is

Tyrosine tRNA precursor molecule polynucleotide sequence.

Evidence suggests that these regions, which can be trimmed in vitro by a nuclease activity in crude cell extracts, are involved in the control of cell tyrosine tRNA levels.

Study of RNA Secondary Structure Prediction Algorithms

The method to predict RNA secondary structure is introduced in two ways, including the mathematic models and main algorithms and the existing problems are pointed out.



Detailed Molecular Model for Transfer Ribonucleic Acid

A new model for transfer ribonucleic acid seems to explain the available experimental evidence better than do the models proposed hitherto.

Sequence of a Ribosome Binding Site in Bacteriophage Qβ-RNA

A sequence of twenty-six nucleotides which includes the initiation region of the coat protein cistron of Qβ bacteriophage has been isolated and determined. The region contains the sequence UUUGA.

Internal Organization of the Ribosome

The conformations of RNA in yeast ribosomes and in the free state are similar. The ribosomal proteins are believed to be in the interior and associated with non-helical parts of the RNA and probably

Derivation of the Secondary Structure of 5S RNA from its Binding of Complementary Oligonucleotides

Using the oligonucleotide binding procedure outlined in the previous article, the secondary structure of 5S RNA has been explored. Most of the unpaired sequences have been identified, although the

Nucleotide Sequences Present within the 16S Ribosomal RNA of Escherichia coli

Sequence analysis has been performed on 125 different oligonucleotides arising from the digestion of 16S rRNA with T1 ribonuclease. A preliminary study has also been made of a large internal fragment.

Polypeptide Chain Initiation: Nucleotide Sequences of the Three Ribosomal Binding Sites in Bacteriophage R17 RNA

The initiator regions of the three cistrons of R17 bacteriophage RNA have been isolated and sequenced. All three regions contain a UGA triplet as well as the expected AUG and two contain the sequence

Nucleotide Sequence from the Polypeptide Chain Termination Region of the Coat Protein Cistron in Bacteriophage R17 RNA

The nucleotide sequence of a fragment of R17 RNA, which corresponds to the last six amino-acids of the bacteriophage coat protein, and extends on the 3′ side of the coat protein cistron for

Nucleotide Sequence from the Coat Protein Cistron of R17 Bacteriophage RNA

The sequence of fifty-seven nucleotides in the coat protein cistron of phage R17 RNA directly confirms the genetic code, shows that the code used by the phage is degenerate and suggests that highly

Sequence of the First 175 Nucleotides from the 5′ Terminus of Qβ RNA synthesized in vitro

The nucleotide sequence of the 5′ end of bacteriophage Qβ RNA has been determined by a new method involving partial synthesis of the RNA in vitro and a very stable hydrogen-bonded loop seems to exist close to the 5″ end of the molecule.