Estimation of Inhibitory Effect against Tyrosinase Activity through Homology Modeling and Molecular Docking

Abstract

Tyrosinase is a key enzyme in melanogenesis. Generally, mushroom tyrosinase from A. bisporus had been used as a model in skin-whitening agent tests employed in the cosmetic industry. The recently obtained crystal structure of bacterial tyrosinase from B. megaterium has high similarity (33.5%) to the human enzyme and thus it was used as a template for… (More)
DOI: 10.1155/2015/262364

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