Estimation of DNA Sequence Context-dependent Mutation Rates Using Primate Genomic Sequences

  title={Estimation of DNA Sequence Context-dependent Mutation Rates Using Primate Genomic Sequences},
  author={Wei Zhang and Gerard G. Bouffard and Susan S. Wallace and Jeffrey P. Bond},
  journal={Journal of Molecular Evolution},
It is understood that DNA and amino acid substitution rates are highly sequence context-dependent, e.g., C→T substitutions in vertebrates may occur much more frequently at CpG sites and that cysteine substitution rates may depend on support of the context for participation in a disulfide bond. Furthermore, many applications rely on quantitative models of nucleotide or amino acid substitution, including phylogenetic inference and identification of amino acid sequence positions involved in… CONTINUE READING
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