Estimation of Agitation Intensity in the GI Tract in Humans and Dogs Based on in Vitro/in Vivo Correlation

@article{Katori1995EstimationOA,
  title={Estimation of Agitation Intensity in the GI Tract in Humans and Dogs Based on in Vitro/in Vivo Correlation},
  author={Noriko Katori and Nobuo Aoyagi and Tadao Terao},
  journal={Pharmaceutical Research},
  year={1995},
  volume={12},
  pages={237-243}
}
In this study, we assessed the hydrodynamic flow around a dosage form in the GI tract in humans by comparing the characteristics of in vitro and in vivo release of two different types of controlled release acetaminophen (paracetamol) tablets, A and B. The former tablet showed an agitation speed-dependent release at a high speed range (50–100 rpm), whereas the latter showed this characteristic at a low speed range (10–50 rpm). The mean release amount-time profiles of tablets A and B in humans… CONTINUE READING

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