Estimation and assessment of raw copy numbers at the single locus level

@article{Bengtsson2008EstimationAA,
  title={Estimation and assessment of raw copy numbers at the single locus level},
  author={H. Bengtsson and R. Irizarry and B. Carvalho and T. Speed},
  journal={Bioinformatics},
  year={2008},
  volume={24 6},
  pages={
          759-67
        }
}
MOTIVATION Although copy-number aberrations are known to contribute to the diversity of the human DNA and cause various diseases, many aberrations and their phenotypes are still to be explored. The recent development of single-nucleotide polymorphism (SNP) arrays provides researchers with tools for calling genotypes and identifying chromosomal aberrations at an order-of-magnitude greater resolution than possible a few years ago. The fundamental problem in array-based copy-number (CN) analysis… Expand
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