Estimating use-dependent synaptic gain in autonomic ganglia by computational simulation and dynamic-clamp analysis.

Abstract

Biological gain mechanisms regulate the sensitivity and dynamics of signaling pathways at the systemic, cellular, and molecular levels. In the sympathetic nervous system, gain in sensory-motor feedback loops is essential for homeostatic regulation of blood pressure and body temperature. This study shows how synaptic convergence and plasticity can interact… (More)

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