Estimating treatment effects in randomized clinical trials in the presence of non-compliance.

@article{Nagelkerke2000EstimatingTE,
  title={Estimating treatment effects in randomized clinical trials in the presence of non-compliance.},
  author={Nico J. D. Nagelkerke and V{\'a}clav Fidler and Roos Bernsen and M. W. Borgdorff},
  journal={Statistics in medicine},
  year={2000},
  volume={19 14},
  pages={1849-64}
}
In clinical trials where patients are randomized between two treatment arms, not all patients comply with the treatment they were randomly assigned to. The reasons for (non)compliance may be associated with the outcome variable and thereby act as confounders. The standard way of analysing such trials is by the 'intention-to-treat' principle, which allows the use of permutation tests. Conclusions drawn from such tests do not depend on untested assumptions such as absence of confounding. However… CONTINUE READING