Estimating transmitter release rates from postsynaptic current fluctuations.

  title={Estimating transmitter release rates from postsynaptic current fluctuations.},
  author={Erwin Neher and Takeshi Sakaba},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={21 24},
A method is presented that allows one to estimate transmitter release rates from fluctuations of postsynaptic current records under conditions of stationary or slowly varying release. For experimental applications, we used the calyx of Held, a glutamatergic synapse, in which "residual current," i.e., current attributable to residual glutamate in the synaptic cleft, is present. For a characterization of synaptic transmission, several postsynaptic parameters, such as the mean amplitude of the… CONTINUE READING
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