Estimating the variability of substitution rates.

@article{Bulmer1989EstimatingTV,
  title={Estimating the variability of substitution rates.},
  author={Michael Bulmer},
  journal={Genetics},
  year={1989},
  volume={123 3},
  pages={615-9}
}
Suppose that amino acid or nucleotide data are available for a homologous gene in several species which diverged from a common ancestor at about the same time and that substitution rates between all pairs of species are calculated, correcting as necessary for multiple substitutions and for back and parallel substitutions. The variances and covariances of these corrected substitution rates are evaluated, and are used to construct a new test for uniformity (constancy of the molecular clock) and… CONTINUE READING

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