Estimating the stoichiometry of human immunodeficiency virus entry.

@article{Magnus2009EstimatingTS,
  title={Estimating the stoichiometry of human immunodeficiency virus entry.},
  author={Carsten Magnus and Peter Rusert and Sebastian Bonhoeffer and Alexandra Trkola and Roland R. Regoes},
  journal={Journal of virology},
  year={2009},
  volume={83 3},
  pages={1523-31}
}
To enter target cells, human immunodeficiency virus (HIV) first attaches to the cells and fuses with the cell membrane. Attachment and fusion involve envelope glycoprotein trimers on the surface of the virion and the CD4 receptor and chemokine coreceptors on the surface of the target cell. The stoichiometry of entry, that is, the number of bonds between such trimers and CD4 that are required for infection, is unknown. Pseudotyped virions that express mixed trimers consisting of functional and… CONTINUE READING