Estimating the role of thymic output in HIV infection.

  title={Estimating the role of thymic output in HIV infection.},
  author={Rob J de Boer},
  journal={Current opinion in HIV and AIDS},
  volume={1 1},
PURPOSE OF REVIEW The mechanisms by which infection with CCR5 tropic HIV causes the depletion of naive CD4+ and CD8+ T cells are poorly understood. As HIV infection affects the thymus, one hypothesis is 'reduced thymic output'. As HIV infection is associated with hyperactivation, another hypothesis is 'depletion by activation'. The best technique that is currently available for measuring thymic output in humans is to quantify TCR excision circles (TRECs) in peripheral T cells. Unfortunately… CONTINUE READING

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