• DOI:10.1016/J.JMB.2004.06.058
Corpus ID: 8881321

Estimating the prevalence of protein sequences adopting functional enzyme folds.

@article{Axe2004EstimatingTP,
  title={Estimating the prevalence of protein sequences adopting functional enzyme folds.},
  author={D. Axe},
  journal={Journal of molecular biology},
  year={2004},
  volume={341 5},
  pages={
          1295-315
        }
}

D. Axe

Published 2004

Biology, Medicine

Journal of molecular biology

Proteins employ a wide variety of folds to perform their biological functions. [...] Key Method An alignment of homologous domain sequences is used to deduce the pattern of hydropathic constraints along chains that form the domain fold. Starting with a weakly functional sequence carrying this signature, clusters of ten side-chains within the fold are replaced randomly, within the boundaries of the signature, and tested for function. The prevalence of low-level function in four such experiments indicates that…Expand Abstract

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