Estimating the impact of vaccination on acute simian-human immunodeficiency virus/simian immunodeficiency virus infections.

@article{Petravic2008EstimatingTI,
  title={Estimating the impact of vaccination on acute simian-human immunodeficiency virus/simian immunodeficiency virus infections.},
  author={Janka Petravic and Ruy M. Ribeiro and Danilo R. Casimiro and Joseph J Mattapallil and Mario Roederer and John Shiver and Miles P. Davenport},
  journal={Journal of virology},
  year={2008},
  volume={82 23},
  pages={11589-98}
}
The dynamics of HIV infection have been studied in humans and in a variety of animal models. The standard model of infection has been used to estimate the basic reproductive ratio of the virus, calculated from the growth rate of virus in acute infection. This method has not been useful in studying the effects of vaccination, since, for the vaccines developed so far, early growth rates of virus do not differ between control and vaccinated animals. Here, we use the standard model of viral… CONTINUE READING