Estimating the heritability of reporting stressful life events captured by common genetic variants.

@article{Power2013EstimatingTH,
  title={Estimating the heritability of reporting stressful life events captured by common genetic variants.},
  author={Robert A. Power and Tanja S H Wingenbach and Sarah Cohen-woods and Rudolf Uher and Mandy Y. M. Ng and Amy W. Butler and Marcus Ising and Nicholas Craddock and Michael J Owen and Ania Korszun and Lisa E. Jones and Ian Jones and Michael Gill and John P. Rice and Wolfgang Maier and A. Zobel and Ole Mors and Anna S Placentino and Marcella Rietschel and Susanne Lucae and Florian Holsboer and Elisabeth B. Binder and Robert Keers and Federica Tozzi and Pierandrea Muglia and Gerome Breen and Ian W. Craig and Bertram M{\"u}ller-Myhsok and James L Kennedy and Jillian Strauss and John B Vincent and Cathryn M. Lewis and A. Elaine Farmer and Peter McGuffin},
  journal={Psychological medicine},
  year={2013},
  volume={43 9},
  pages={1965-71}
}
BACKGROUND Although usually thought of as external environmental stressors, a significant heritable component has been reported for measures of stressful life events (SLEs) in twin studies. Method We examined the variance in SLEs captured by common genetic variants from a genome-wide association study (GWAS) of 2578 individuals. Genome-wide complex trait analysis (GCTA) was used to estimate the phenotypic variance tagged by single nucleotide polymorphisms (SNPs). We also performed a GWAS on the… CONTINUE READING