Estimating the efficacy of preexposure prophylaxis for HIV prevention among participants with a threshold level of drug concentration.

@article{Dai2013EstimatingTE,
  title={Estimating the efficacy of preexposure prophylaxis for HIV prevention among participants with a threshold level of drug concentration.},
  author={James Y. Dai and Peter B. Gilbert and James P. Hughes and Elizabeth R. Brown},
  journal={American journal of epidemiology},
  year={2013},
  volume={177 3},
  pages={256-63}
}
Assays for detecting levels of antiretroviral drugs in study participants are increasingly popular in preexposure prophylaxis (PrEP) trials, since they provide an objective measure of adherence. Current correlation analyses of drug concentration data are prone to bias. In this article, we formulate the causal estimand of prevention efficacy among drug compliers, those who would have had a threshold level of drug concentration had they been assigned to the drug arm of the trial. The… CONTINUE READING
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