Estimating the agreement and diagnostic accuracy of two diagnostic tests when one test is conducted on only a subsample of specimens.

@article{Katki2012EstimatingTA,
  title={Estimating the agreement and diagnostic accuracy of two diagnostic tests when one test is conducted on only a subsample of specimens.},
  author={Hormuzd A. Katki and Yan Li and David W Edelstein and Philip E. Castle},
  journal={Statistics in medicine},
  year={2012},
  volume={31 5},
  pages={436-48}
}
We focus on the efficient usage of specimen repositories for the evaluation of new diagnostic tests and for comparing new tests with existing tests. Typically, all pre-existing diagnostic tests will already have been conducted on all specimens. However, we propose retesting only a judicious subsample of the specimens by the new diagnostic test. Subsampling minimizes study costs and specimen consumption, yet estimates of agreement or diagnostic accuracy potentially retain adequate statistical… CONTINUE READING