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# Estimating the Null and the Proportion of non-Null Effects in Large-Scale Multiple Comparisons

@inproceedings{Jin2006EstimatingTN, title={Estimating the Null and the Proportion of non-Null Effects in Large-Scale Multiple Comparisons}, author={Jiashun Jin and T. Tony Cai}, year={2006} }

- Published 2006

An important issue raised by Efron [7] in the context of large-scale multiple comparisons is that in many applications the usual assumption that the null distribution is known is incorrect, and seemingly negligible differences in the null may result in large differences in subsequent studies. This suggests that a careful study of estimation of the null is indispensable. In this paper, we consider the problem of estimating a null normal distribution, and a closely related problem, estimation of… CONTINUE READING

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