Estimating the Diversity, Completeness, and Cross-Reactivity of the T Cell Repertoire

@inproceedings{Zarnitsyna2013EstimatingTD,
  title={Estimating the Diversity, Completeness, and Cross-Reactivity of the T Cell Repertoire},
  author={Veronika I Zarnitsyna and Brian D Evavold and Louis Schoettle and Joseph N Blattman and Rustom Antia},
  booktitle={Front. Immunol.},
  year={2013}
}
In order to recognize and combat a diverse array of pathogens the immune system has a large repertoire of T cells having unique T cell receptors (TCRs) with only a few clones specific for any given antigen. We discuss how the number of different possible TCRs encoded in the genome (the potential repertoire) and the number of different TCRs present in an individual (the realized repertoire) can be measured. One puzzle is that the potential repertoire greatly exceeds the realized diversity of na… CONTINUE READING

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