Estimating selection pressures from limited comparative data.

  title={Estimating selection pressures from limited comparative data.},
  author={Joshua B. Plotkin and Jonathan Dushoff and Michael M Desai and H. B. Fraser},
  journal={Molecular biology and evolution},
  volume={23 8},
We recently introduced a novel method for estimating selection pressures on proteins, termed "volatility," which requires only a single genome sequence. Some criticisms that have been levied against this approach are valid, but many others are based on misconceptions of volatility, or they apply equally to comparative methods of estimating selection. Here, we introduce a simple regression technique for estimating selection pressures on all proteins in a genome, on the basis of limited… CONTINUE READING

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