Estimating selection by comparing synonymous and substitutional changes

@article{Smith1994EstimatingSB,
  title={Estimating selection by comparing synonymous and substitutional changes},
  author={John Maynard Smith},
  journal={Journal of Molecular Evolution},
  year={1994},
  volume={39},
  pages={123-128}
}
A higher ratio of substitutional to synonymous changes in between-species than in within-species comparisons has been taken as evidence for positive selection changing amino acids. A model is presented in which a difference of this kind arises as a result of purely neutral mutations, provided that the “species” compared are sufficiently different to approach a steady state between forward and backward mutation. In Neissseria, substitutions are twice as frequent, relative to synonymous changes… CONTINUE READING

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Role of interspecies transfer of chromosomal genes in the evolution of penicillin resistance in pathogenic and commensal Neisseria species

  • BG Spratt, LD Bowler, Zhang Q-Y, J Zhou, J MaynardSmith
  • J Mol Evol
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