Estimating selection by comparing synonymous and substitutional changes

  title={Estimating selection by comparing synonymous and substitutional changes},
  author={John Maynard Smith},
  journal={Journal of Molecular Evolution},
A higher ratio of substitutional to synonymous changes in between-species than in within-species comparisons has been taken as evidence for positive selection changing amino acids. A model is presented in which a difference of this kind arises as a result of purely neutral mutations, provided that the “species” compared are sufficiently different to approach a steady state between forward and backward mutation. In Neissseria, substitutions are twice as frequent, relative to synonymous changes… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
8 Citations
3 References
Similar Papers


Publications citing this paper.


Publications referenced by this paper.
Showing 1-3 of 3 references

Role of interspecies transfer of chromosomal genes in the evolution of penicillin resistance in pathogenic and commensal Neisseria species

  • BG Spratt, LD Bowler, Zhang Q-Y, J Zhou, J MaynardSmith
  • J Mol Evol
  • 1992

Similar Papers

Loading similar papers…