Estimating relative fitness in viral competition experiments.

  title={Estimating relative fitness in viral competition experiments.},
  author={Athanasius F. M. Mar{\'e}e and Wilco Keulen and Charles A. Boucher and Rob J de Boer},
  journal={Journal of virology},
  volume={74 23},
The relative fitness of viral variants has previously been defined as the slope of the logarithmic ratio of the genotype or phenotype frequencies in time plots of pairwise competition experiments. Developing mathematical models for such experiments by employing the conventional coefficient of selection s, we demonstrate that this logarithmic ratio gives the fitness difference, rather than the relative fitness. This fitness difference remains proportional to the actual replication rate realized… CONTINUE READING


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Introduction to theoretical population genetics

  • T. Nagylaki
  • 1992
Highly Influential
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