• Biology, Medicine
  • Published in Genetics 1992

Estimating polygenic models for multivariate data on large pedigrees.

@article{Thompson1992EstimatingPM,
  title={Estimating polygenic models for multivariate data on large pedigrees.},
  author={Elizabeth A Thompson and Ruth G. Shaw},
  journal={Genetics},
  year={1992},
  volume={131 4},
  pages={
          971-8
        }
}
We have developed algorithms for the likelihood estimation of additive genetic models for quantitative traits on large pedigrees. The approach uses the expectation L-maximization (EM) algorithm, but avoids intensive computation. In this paper, we focus on extensions of previous work to the case of multivariate data. We exemplify the approach by analyses of bivariate data on a four-generation, 949-member pedigree of the snail Lymnaea elodes, and on a three-generation pedigree of the guppy… CONTINUE READING

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