Estimating linkage disequilibrium between a polymorphic marker locus and a trait locus in natural populations.

@article{Luo1999EstimatingLD,
  title={Estimating linkage disequilibrium between a polymorphic marker locus and a trait locus in natural populations.},
  author={Zewei Luo and S{\'a}ndor Suhai},
  journal={Genetics},
  year={1999},
  volume={151 1},
  pages={359-71}
}
Positional cloning of gene(s) underlying a complex trait requires a high-resolution linkage map between the trait locus and genetic marker loci. Recent research has shown that this may be achieved through appropriately modeling and screening linkage disequilibrium between the candidate marker locus and the major trait locus. A quantitative genetics model was developed in the present study to estimate the coefficient of linkage disequilibrium between a polymorphic genetic marker locus and a… CONTINUE READING
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