Estimating genetic variability with restriction endonucleases.

  title={Estimating genetic variability with restriction endonucleases.},
  author={Richard R. Hudson},
  volume={100 4},
The estimation of the amount of sequence variation in samples of homologous DNA segments is considered. The data are assumed to have been obtained by restriction endonuclease digestion of the segments, from which the numbers and frequencies of the cleavage sites in the sample are determined. An estimator, p, of the proportion of sites that are polymorphic in the sample is derived without assuming any particular population genetic model for the evolution of the population. The estimator is very… CONTINUE READING