Estimating diversifying selection and functional constraint in the presence of recombination.

@article{Wilson2006EstimatingDS,
  title={Estimating diversifying selection and functional constraint in the presence of recombination.},
  author={Daniel J. Wilson and Gilean McVean},
  journal={Genetics},
  year={2006},
  volume={172 3},
  pages={1411-25}
}
Models of molecular evolution that incorporate the ratio of nonsynonymous to synonymous polymorphism (dN/dS ratio) as a parameter can be used to identify sites that are under diversifying selection or functional constraint in a sample of gene sequences. However, when there has been recombination in the evolutionary history of the sequences, reconstructing a single phylogenetic tree is not appropriate, and inference based on a single tree can give misleading results. In the presence of high… CONTINUE READING
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